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Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction) by blocking a certain enzyme (phosphodiesterase-PDE5) in the body. In combination with sexual stimulation sildenafil works by helping the blood flow into the penis to achieve and maintain an erection.This drug is not indicated for use in women.Use of this drug does not protect against sexually transmitted diseases (e.g. HIV hepatitis B gonorrhea syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details.How to use Kamagra OralRead the Patient Information Leaflet provided by your pharmacist before you start taking sildenafil and each time you get a refill. If you have any questions consult your doctor or pharmacist.This drug is taken by mouth as needed at least 30 minutes but no more than 4 hours before sexual activity (1 hour before is the most effective). Do not take more often than once daily and take as directed.A high fat meal may delay the time of onset of this drug.Avoid eating grapefruit or drinking grapefruit juice while you are being treated with this medication unless your doctor instructs you otherwise.The dosage is based on your medical condition response to therapy and other medications you may be taking (see also Drug Interactions section). Consult your doctor or pharmacist for more details.

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Medicine News : The first transgenic mouse model of a rare and severe type of autism called Timothy Syndrome is improving the scientific understanding of autism spectrum disorder in general and may help researchers design more targeted interventions and treatments. The research is described in a paper published last week by scientists at the University at Buffalo and Stanford University in the Proceedings of the National Academy of Sciences. The transgenic mouse developed at UB exhibits the repetitive physical behaviors, altered social behaviors and impaired communication abilities associated not just with Timothy Syndrome but with autism spectrum disorder in general. The fact that this mouse exhibited so many behavioral parallels with humans diagnosed with autism was both surprising and encouraging, the researchers say. "This animal and the syndrome that it is associated with, provides one of the best chances to understand the underlying mechanisms of autism," says Randall L. Rasmusson, PhD, professor of physiology and biophysics in the UB School of Medicine and Biomedical Sciences and co-author on the PNAS paper.
 
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